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The function of SIK1 in tumorigenesis. SIK1 is a tumor suppressor gene, which performs an important regulatory function in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and has an effect on cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 might also marke